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Diagnosis

Children – Appendicitis

childAppendicitis most commonly affects children age 10–19, with an overall incidence of approximately 20 cases per 10,000 population annually.Among those under age 20, infants age 0–4 have the lowest incidence of appendicitis (2 cases per 10,000 annually), but up to two-thirds will present with perforation. Perforation is common because infants often present later in their disease course and because of the difficulty in obtaining an accurate history. The diagnosis is further complicated by diseases of childhood that can mimic appendicitis. For instance, mesenteric adenitis, an inflammation of the mesenteric lymph nodes secondary to upper respiratory tract infection, can present with fever and right lower quadrant pain. Streptococcal pharyngitis and bacterial meningitis can also present with fever, nausea, and abdominal pain. These diagnoses should be considered when evaluating children for suspected appendicitis.

Pregnancy – Appendicitis

pregnancyThe diagnosis of acute appendicitis in the pregnant patient can be particularly challenging, as nausea, anorexia, and abdominal pain may be symptoms of both appendicitis and normal pregnancy. In addition, the gravid uterus can displace the abdominal viscera, shifting the location of the appendix from the right lower quadrant. Appendicitis affects 1 in every 1,400 pregnancies, an incidence similar to that of the nonpregnant female population.It can occur in any trimester, with perhaps a slight increase in frequency during the second trimester. Perforation is more common in the third trimester, however, and results from a longer duration from the onset of symptoms to operation. The differential diagnosis of appendicitis includes not only the conditions possible in nonpregnant women, but also certain conditions specific to pregnancy: ectopic pregnancy, chorioamnionitis, preterm labor, placental abruption, and round ligament pain.

Appendicitis – The Differential Diagnosis

Because many of its signs and symptoms are nonspecific, the differential diagnosis of acute appendicitis is extensive and includes virtually all possible abdominal sources of pain, as well as some nonabdominal sources (see table below). However, some diagnoses are more likely than others in certain patient groups. For instance, in young males with a suggestive history and physical examination, acute appendicitis is the most likely cause of right lower quadrant pain. Meckel’s diverticulitis causes similar symptoms, but is relatively uncommon. Gastroenteritis is considerably more common and should be expected when nausea and vomiting precede the abdominal pain, or when diarrhea is a prominent symptom. Crohn’s disease affecting the terminal ileum may resemble appendicitis in its initial presentation, but on further questioning, the patient typically describes a subacute course including fever, weight loss, and pain.

Imaging Studies of Appendicitis

ct appendixThe potential imaging modalities for diagnosis of acute appendicitis include plain radiographs, ultrasound, and computed tomography. Prior to the widespread use of modern imaging techniques, plain abdominal films were often obtained in patients with abdominal pain, and a right lower quadrant fecalith (or appendicolith) was considered pathognomonic for acute appendicitis. A number of studies question this teaching, however. Teicher and colleagues reviewed the abdominal radiographs of 200 appendectomy patients, 100 with pathologically proven appendicitis and 100 with a normal appendix. Of those with appendicitis, 10.5% had an appendicolith on x-ray, compared to 3.3% of those without appendicitis. An extensive review of appendectomy specimens at the Mayo Clinic showed that fecaliths or appendiceal calculi were present in 9% of patients with nonperforated appendicitis and 21% of those with perforated appendicitis. Interestingly, fecaliths were also present in 7% of patients with suspected appendicitis who had a pathologically normal appendix, and 2% of patients who had an appendectomy for other reasons.